Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy
2016
Metformin exhibits anticancer properties and is currently being explored as a therapeutic option for a variety of cancer types. Epidemiological studies demonstrate associations between metformin use in patients with type 2 diabetes and decreased cancer incidence and cancer-related mortality (Evans et al., 2005). Metformin also exhibits inhibitory effects on cancer cells in vitro and in mouse models (Anisimov et al., 2005; Zakikhani et al., 2006). Its mechanism of action is believed to involve both indirect (insulin-dependent) and direct (insulin-independent) effects.
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