Long-term Pharmacological Activation of PPARγDoes not Prevent Left Ventricular Remodeling in Dogs with Advanced Heart Failure

Background Peroxisome proliferator-activated receptor γ (PPARγ) activators affect the myocardium through inhibition of inflammatory cytokines and metabolic modulation but their effect in the progression of heart failure is unclear. In the present study, we examined the effects of the PPARγ activator, GW347845 (GW), on the progression of heart failure.