Contribution of Circulatory Disturbances in Subchondral Bone to the Pathophysiology of Osteoarthritis

Purpose of Review This review describes the contributions of abnormal bone circulation to the pathophysiology of osteoarthritis. Combining dynamic imaging with MRI and PET with previous observations reveals that venous stasis and a venous outlet syndrome is most likely the key circulatory pathology associated with the initiation or progression of osteoarthritis.