Interrelation Between Dry Mouth and Flammer Syndromes: Neglected Risks in Youth and New Concepts of Personalised Prevention: International Multi-centre Study

“Dry mouth” syndrome (chronic hyposalivation) can be caused by a number of pathophysiological conditions such as acute and chronic stress exposure, abnormal body weight (both – too high and too low), eating disorders (such as Anorexia nervosa), metabolic syndrome(s), Sjogren’s and Sicca syndromes, drugs and head/neck radiotherapy application. In turn, the chronic hyposalivation as a suboptimal health condition significantly reduces quality of life, may indicate a systemic dehydration, provoke and contribute to a number of pathologies such as a strongly compromised protection of the oral cavity, chronic infections and inflammatory processes, periodontitis, voice and digestive disorders, amongst others. Consequently, “dry mouth” syndrome might be extremely useful as an indicator for an in-depth diagnostics of both – co-existing and snowballing health-threating conditions. However, predictive diagnostics, targeted prevention and personalisation of treatments are evidently underdeveloped for individuals at high risk suffering from the “dry mouth” syndrome.