Age and Sex Infl uence Cystatin Ci n Adolescents With and Without Type 1 Diabetes

RESULTSdCystatin C (0.698 6 0.083 vs. 0.688 6 0.127 mg/L, P = 0.40) was similar by diabetes status. In multiple linear regression, cystatin C was associated with age and serum creatinine in nondiabetic subjects and sex, age, and serum creatinine in subjects with diabetes (P , 0.05). CONCLUSIONSdThese data suggest sex differences and age-related changes in cystatin C in adolescents with type 1 diabetes. An understanding of these changes is needed to determine the potential role of cystatin C as a marker of renal function in this population. Diabetes Care 34:2360–2362, 2011