Journal Club: MRI reveals acute inflammation in cortical lesions during early MS

Early multiple sclerosis is characterized by immune-associated demyelination of CNS axons. In a recent Neurology® article, Maranzano et al. evaluated MRI scans of patients with early multiple sclerosis to study the evolution of leukocortical lesions. Their novel data suggest that acute inflammation after blood–brain barrier leakage may contribute to gray matter cortical lesions in early multiple sclerosis.