Abstract 16173: Changes in Extracellular Circulating MicroRNAs Are Associated With a Weight Loss Intervention in Filipinos

Introduction: A moderate amount of weight loss through lifestyle modification is an effective treatment for prevention of type 2 diabetes (T2D) for some individuals, however others remain at risk. Filipinos have one of the highest prevalence of T2D. MicroRNAs (miRs) are circulating biomarkers associated with risk factors for T2D and may also be linked to lifestyle modification responses. Hypothesis: Expression of circulating miRs will change in response to a 3-month tailored weight loss intervention. Methods: Eight Filipino participants (38 ± 6 years, 50% men) who completed a tailored weight loss intervention were analyzed. Blood was collected at enrollment and after 3-months of the intervention. The Firefly Bioworks Multiplex Circulating MicroRNA Assay was used to quantify 337 miRs. Fold changes and student’s t-test were calculated. Results: After 3-months of the intervention, the mean weight loss was 9 ± 4 pounds. Total cholesterol (-14 ± 31mg/dL), LDL-c (-5 ± 10mg/dL), triglycerides (-55 ± 186mg/dL), f...