Novel Equations to Estimate Lean Body Mass in Maintenance Hemodialysis Patients

Background Lean body mass (LBM) is an important nutritional measure representing muscle mass and somatic protein in hemodialysis patients, for whom we developed and tested equations to estimate LBM. Study Design A study of diagnostic test accuracy. Setting & Participants The development cohort included 118 hemodialysis patients with LBM measured using dual-energy x-ray absorptiometry (DEXA) and near-infrared (NIR) interactance. The validation cohort included 612 additional hemodialysis patients with LBM measured using a portable NIR interactance technique during hemodialysis. Index Tests 3-month averaged serum concentrations of creatinine, albumin, and prealbumin; normalized protein nitrogen appearance; midarm muscle circumference (MAMC); handgrip strength; and subjective global assessment of nutrition. Reference Test LBM measured using DEXA in the development cohort and NIR interactance in validation cohorts. Results In the development cohort, DEXA and NIR interactance correlated strongly (r = 0.94, P 2 ≥ 0.88), although in higher LBM ranges, they tended to underestimate it. Median (95% confidence interval) differences and interquartile range for differences between equation estimates and NIR interactance–measured LBM were 3.4 (−3.2 to 12.0) and 3.0 (1.1-5.1) kg for serum creatinine and 4.0 (−2.6 to 13.6) and 3.7 (1.3-6.0) kg for MAMC, respectively. Limitations DEXA measurements were obtained on a nondialysis day, whereas NIR interactance was performed during hemodialysis treatment, with the likelihood of confounding by volume status variations. Conclusions Compared with reference measures of LBM, equations using serum creatinine level, MAMC, or handgrip strength and demographic variables can estimate LBM accurately in long-term hemodialysis patients.