Abstract 410: Link Between Hypertension and Insulin Resistance in South Asians: Implications for Prevention of Cardiovascular Complications

Background: The coexistence of hypertension (HTN) and insulin resistance (IR) substantially increases cardiovascular risk (CVR) and diabetes (DM) perhaps by endothelial dysfunction from low-grade chronic inflammation and oxidative stress. South Asian immigrants in United States (SA-USA) have a high salt consumption, IR, and salt sensitivity. The triglyceride (TG)/ HDL ratio is a known correlate of IR with ratios ≥3.5 associated with high risk. It is unknown whether SA-USA have a coexistence of HTN, IR, and DM resulting in high CVR. Methods: We reviewed the clinical history and Vertical Auto Profile technology (VAP) + lipid panel utilizing ultracentrifugation to directly measure lipid sub-fractions, for 348 participants (42% women) of the South Asian Cardiovascular Registry. Prevalent DM and Pre-DM were defined as HbA1c ≥ 6.5 and 5.7-6.4, respectively. Results: Of the 348 participants, mean age 55.3 years, 128 had HTN and were stratified into clinical risk groups based on fasting TG (mg/dL) levels: TG 500 (n=3). The corresponding TG/HDL ratios were: 1.7, 3.5, 6.2, and 20.4, respectively; the median TG (mg/dL) levels were: 100, 182, 268, and 572, respectively; the median LDL (mg/dL) levels were: 113, 144, 133, 102, respectively; the rates of DM were: 13%, 17%, 38%, and 67%; and the rates of Pre-DM/DM were: 62%, 63%, 78%, and 67%, respectively. Relative Risk for DM with TG/HDL≥ 3.5 was 3.6 (46 % had TG/HDL ≥ 3.5). Conclusions: South Asian immigrants participating in a community registry have: 1) A high rate of coexistence of HTN and IR portending a very high relative risk of diabetes. 2) A discordance of LDL levels and IR in patients with HTN. As IR gets higher, the relative risk of diabetes goes up but LDL levels decline. Clinical Implications: South Asian immigrants in the United States have a diet that is very high in salt, simple carbohydrates, and saturated fat. Many are vegetarian with no consumption of fish. Public health efforts to help reduce risk of CVD in South Asian immigrants should focus on low salt diet, with consumption of multigrain complex carbohydrates, poly-unsaturated fatty acids, omega-3 fatty acids, and lifestyle changes to reduce metabolic syndrome, diabetes, and hypertension.