Incidence and evolution of sepsis-induced cardiomyopathy in a cohort of patients with sepsis and septic shock

Abstract Objective The aim of this study was to establish the incidence of septic cardiomyopathy (SM) in patients with sepsis and septic shock, to describe its characteristics and testing its evolution. Design Prospective cohort study. Participants We included 57 consecutive patients admitted to Intensive Care Unit, who met criteria of sepsis and septic shock. Principal variables of interest Clinical and biochemical variables were analyzed. An echocardiogram was performed in the first 24 h of admission, determining myocardial function parameters, and if the patients had left ventricular ejection fraction (LVEF) Ambit Intensive medical and surgical Care Service for Adults in University Hospital. Results The mean age of the patients was 62.1 ± 16.3 years. 58% were males. 22.8% had left ventricular dysfunction. The mean LVEF in patients with MS was lower than those without SM (34.1 ± 10.6 vs 60.7 ± 6.94%, P P  = .04). Patients with SM had higher levels of procalcitonin (47.1 ± 35.4 vs 18.9 ± 24.5; P  = .02) and higher score on the Sequential Organ Failure Assessment (SOFA score) (9.91 ± 3.82 vs 7.47 ± 3.41; P  = .037). Mortality was not significantly different between both groups [4 (30.8%) vs 4 (9.1%); P  = .07]. Conclusions SM is not uncommon and is related to a higher scores on the severity scales. In the survivors, LVEF normalized after the recovery of the acute event.