Association between genetic loci linked to HDL-C levels and Indian patients with CAD: a pilot study

Objective To examine the association between loci linked to high-density lipoprotein cholesterol (HDL-C) levels and coronary artery disease (CAD). Methods A pilot study consisting of age-matched and gender-matched angiographically confirmed CAD cases (n=150) and non-CAD controls (n=150) was performed to test an association. Illumina9s Human Cardio-Metabo BeadChip containing 3112 variants associated with HDL-C levels was used for genotyping. Results A preliminary analysis identified 36 variants from 16 genes that were statistically significant (p MADD ), rs749067 ( MADD ), rs367070 ( LILRA3 ) and rs330921 ( PPP1R3B ) showed modest association with HDL-C levels. Conclusions None of the HDL-C associated loci included in this study were found to be a significant risk factor for CAD. However, the study could replicate the findings of four variants influencing HDL-C levels.