THU0657 ASSOCIATION OF DIET AND SPICES WITH TREATMENT OUTCOME IN ASIAN INDIAN PATIENTS WITH RHEUMATOID ARTHRITIS – A CROSS SECTIONAL STUDY

Background Influence of diet on inflammation, specially foods like fish oil, spices like turmeric, capsaicin, garlic etc. are reported in published literature. However, a well-designed study on this subject amongst Asian Indian patients is lacking. Objectives To analyze whether the type and quantity of intake of various food constituents, with particular reference to Indian spices, makes an impact on the control of disease activity in patients with Rheumatoid arthritis(RA) Methods Patients diagnosed as RA by the ACR 2010 criteria and receiving standard triple drug therapy in our clinic between June 2017 and June 2018, for at least one year were enrolled. Disease activity was assessed during the routine OPD visit. They were administered a food frequency questionnaire [1] pertaining to the quality as well as quantity of food and spice intake. Analysis was done using multivariate logistic regression Results A total of 400 patients were included with 86.75% females. 67.75% patients were in disease remission, 10% had mild disease activity and 22.25% moderate to high disease activity; only 18.09% were vegetarians and the rest consumed non-vegetarian food. Median age was 47.99years(SD 10.67),median duration of illness prior to presentation to our clinic was 7years(IQR 4,10), median ESR was 37mm/hr(IQR 23,52),median CRP was5.34mg/L(IQR 2.04,12.4), and median DAS28CRP was 2.07(IQR 1.64,2.97). Patients with DAS28CRP of 3.2. Statistically higher consumption of ginger, garlic, turmeric and coriander were noted amongst patients in remission. Similar results were obtained when patients with DAS28CRP of 5.1. Nonsignificant numerical differences were noted for intake of food constituents like wheat, total pulse, vegetables, fruit, milk and fish Conclusion Higher consumption of Indian spices like ginger, garlic, turmeric and coriander were found to be associated with better control of disease activity and hence the inflammation, as evidenced by DAS28CRP in patients with Rheumatoid arthritis, receiving standard triple therapy References [1] Shim JS, Oh K, Kim HC. Dietary assessment methods in epidemiologic studies. Epidemiol Health. 2014 Disclosure of Interests None declared