IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia

Abstract Previous studies have established that impaired glucose tolerance (IGT) patients with fasting hyperglycemia (IGT/FH: fasting plasma glucose (FPG) level 6.1–7.0 mmol/l and 2 h PG level of 7.8–11.1 mmol/l) exhibit higher insulin resistance than those with isolated IGT (FPG level n =71), impaired fasting glucose (IFG: n =24), isolated IGT ( n =36), and IGT/FH ( n =23). A urinary albumin-to-creatinine ratio (ACR) from 30 to 300 μg/mg creatinine was counted as microalbuminuria. The prevalence of microalbuminuria was higher in subjects with IGT/FH than in subjects with isolated IGT (26% versus 14%). Logistic regression analysis showed microalbuminuria to be more significantly associated with IGT/FH (OR=3.82, 95% CI 1.09–13.36) than with isolated IGT (OR=1.75, 95% CI 0.50–6.17). While insulin resistance (HOMA-IR) in isolated IGT was not significantly different from that in NGT, insulin resistance in IGT/FH was significantly higher ( P P =0.012). Accordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance.