Personalized monitoring of drug therapy effectiveness based on high-throughput analysis of drugs utilization and inflammatory factors closed functional networks in cardiovascular pathogenesis pathologies

Technical approaches 1. Remote real-time functional monitoring of patients; 2. Genome profiling (NGS); 3. Proteome profiling (IEF, LC MS/MS); 4. Cell function research (Flow cytometry, Live cell imaging); 5. Drugs and metabolites concentration control and association it with genomic constitution (LC MS/MS); 6. Quantification plasma concentration of the drugs and their metabolites, enzymes (LC MS/MS); 7. Immunologic profiling (ELISA, flow cytometry).