Study of pancreases β-cell function in first-degree relatives of type 2 diabetes patients

AIM: To investig the pancreases β-cell function in no-diabetic first-degree relatives of type 2 diabetes mellitus(FDR) patients.METHODS: Collect T2DM first-degree relatives,and divided them into three groups: no-diabetes group with normal sugar tolerance(NGT);no-diabetes with abnormal sugar tolerance(IGT);new-confirmed T2DM.apart from that three group patients,30 normal people with no-related disease risks were also collected as normal control(NC).All four groups of patients were experienced with intravenous glucose tolerance test(IVGTT) and counting the first phase of pancreases function by statistic AIR3-5 and insulin sensitive index(ISI).RESULTS: New-confirmed T2DM patients with the significantly abnormal statistic results about AIR3-5 and ISI,while NGT patients had the abnormal results compared with normal control group but better than T2DM patients.CONCLUSION: Compared with normal group patients,NGT group appeared decrease of pancreases first phase secretes and insulin resistance but not aggravate enough to induce type 2 diabetes.