Abstract 15350: Exercise Training With and Without Ranolazine in Chronic Stable Angina Patients: Effects on Peak Oxygen Consumption, Daily Physical Activity and Quality of Life: A Randomized, Placebo-Controlled, Double-Blind Pilot Study

Introduction: An estimated seven million American adults live with coronary artery disease and chronic angina. Many continue to experience angina despite revascularization and antianginal medications. Ranolazine reduces angina frequency and increases exercise capacity. We hypothesized that exercise plus ranolazine would allow patients to train at greater intensities, leading to improvements in exercise capacity (peak VO2), increased daily physical activity and improved quality of life (QOL). Methods: Sedentary subjects with chronic stable angina were randomized to either ranolazine (n=14) or placebo (n=15) plus a 12-w exercise program. Exercise training was 3 days/w for 30-45 min/session. Peak VO2, physical activity (Actigraph) and QOL (Seattle Angina Questionnaire) were measured pre- and post-training. Results: Peak VO2, daily physical activity and QOL were improved more with ranolazine than placebo. Due to the small size of this pilot study, there were no between-group significant differences. After 2w ...