Correlation between serum 25-hydroxyvitamin D3 and carpal tunnel syndrome in type 2 diabetes

Objective To investigate the relationship between serum 25-OH vitamin D3(25-OHD3)levels and carpal tunnel syndrome(CTS)in type 2 diabetes. Methods Data from 102 patients with type 2 diabetes were collected, and patients were divided into a CTS group(n=29)and a non-CTS group(n=73)according to clinical symptoms, signs, and electrophysiological testing.Fasting venous blood was collected to assay serum 25-OHD3 levels that were compared between the two groups.The correlation between 25-OHD3 and clinical parameters for type 2 diabetes was analyzed. Results The incidence of vitamin D3 deficiency was 65.5%(n=19)in the CTS group and 46.6%(n=34)in the non-CTS group, and the difference was statistically significant(χ2=16.85, P<0.01). Levels of 25-OHD3 were lower in the CTS group(14.13±4.91)μg/L than in the non-CTS group(17.08±3.35)μg/L(t=4.067, P<0.01). Levels of 25-OHD3 were negatively correlated with those of glycosylated hemoglobin(HbA1c)(r=-0.176, P=0.041)and the duration of diabetes(r=-0.29, P=0.01). Conclusions Low 25-OHD3 is a risk factor for carpal tunnel syndrome in type 2 diabetes and is negatively associated with the duration of diabetes and HbA1c in patients with type 2 diabetes. Key words: Diabetes mellitus, type 2; Vitamin D; Carpal tunnel syndrome