Triptolide causes global changes in the microRNAome and transcriptome of pancreatic cancer cells

s / Pancreatology 13 (2013) e1–e94 e51 Results: Etiologies of CP included idiopathic disease (n1⁄416), pancreatic divisum (11), sphincter of Oddi dysfunction (5), genetic /familial (10), and other causes (2). Mean IEQ isolated was 286,228 153,619, and mean IEQ/ kg 4,286 2,244. Higher recipient BMI correlated with greater IEQ (r1⁄40.41 p1⁄40.006) but not IEQ/kg. The area under the curve (AUC) for C-peptide and the peak C-peptide from the IVGTT correlated with higher IEQ isolated (r1⁄40.44, p1⁄40.004 and r1⁄40.42, p1⁄40.005, respectively). Similarly, total IEQ positively correlated with AUC C-peptide (r1⁄40.39, p1⁄40.01) and peak Cpeptide (r1⁄40.34, p1⁄40.03) from the MMTT. Peak C-peptide fromMMTT was particularly predictive in this cohort: 91% of patients with peak C peptide 4 ng/mL received 200,000 IEQ, while 89% of those with peak C-peptide <4 ng/mL received <200,000 IEQ. Glucose levels, glucagon secretion, and HbA1c did not predict islet yield. Discussion: These preliminary results suggest that C-peptide secretion determined from simple metabolic testing may aid in predicting islet yield before TP-IAT.