CARDIAC REHABILITATION PROTOCOL FOR PATIENTS WITH SPONTANEOUS CORONARY ARTERY DISSECTION

fibrinolysis differs based on smoking status. METHODS: The TRANSFER-AMI study randomized patients with STEMI to a routine early invasive (pharmacoinvasive) versus a standard (delayed coronary angiography, with early transfer only for rescue PCI) strategy after fibrinolysis. In this post-hoc subgroup analysis, we compared the efficacy of these strategies among 1,051 patients based on their smoking status, and performed multivariable analysis to evaluate for interaction between smoking status and treatment strategy after adjusting for baseline GRACE risk score. For the purpose of this analysis, ex-smokers were considered non-smokers. RESULTS: Ofthe1,051patients (medianage57years; 79.5%male), 448 (42.6%) were current smokers. Smokers were younger, had fewer cardiovascular risk factors, and lower GRACE risk scores than non-smokers. Smokers had a lower unadjusted rate of the primary composite endpoint of 30-day mortality, re-infarction (re-MI), recurrent ischemia, heart failure, or cardiogenic shock, and fewer deaths or re-infarctions at 30 days, 6 months and 1 year (Table).