Seminal plasma (SP) induces a rapid transforming growth factor beta 1 (TGFβ1)—independent up-regulation of epithelial–mesenchymal transdifferentiation (EMT) and myofibroblastic metaplasia-markers in endometriotic (EM) and endometrial cells

Mohamed Gamal Ibrahim,E. A. Elghonaimy,S. Schäfer,M. Vennemann,Sabine Kliesch,L. Kiesel,Martin Götte,Andreas N. Schüring

Seminal plasma (SP) induces a rapid transforming growth factor beta 1 (TGFβ1)—independent up-regulation of epithelial–mesenchymal transdifferentiation (EMT) and myofibroblastic metaplasia-markers in endometriotic (EM) and endometrial cells

2019

Mohamed Gamal Ibrahim
E. A. Elghonaimy
S. Schäfer
M. Vennemann
Sabine Kliesch
L. Kiesel
Martin Götte
Andreas N. Schüring

Purpose To study if short-term exposure (2 h and 6 h) of endometrial/endometriotic tissues and cells to 10% seminal plasma (SP) can induce EMT/metaplasia.

Keywords:

Endometriosis
Metaplasia
Obstetrics
Mesenchymal stem cell
Diabetes mellitus
Downregulation and upregulation
Cancer research
Transdifferentiation
Transforming growth factor beta
Medicine
Endometrial Stromal Cell
Andrology
Epithelium
Cell culture
Semen
Endometrial biopsy

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