The Effection of Combined Treatment for Intrahepatic Cholestasis of Pregnancy

Objective To investigate the clinical effects of three treatment option for intrahepatic cholestasis of pregnancy(ICP).Methods The patients with intrahepatic cholestasis in pregnancy were randomized to receive signle SAMe,Polyene Phosphatidylcholine or combined treatment for two weeks and the results were compared.Results After combined treatment,there were significant decrease in the degree of the blood level of biochemical parameters such as AST,ALT and TBA(P0.05).Combined with single treated group,the outcome of pregnancy and the situation of newborns were significantly improved.Conclusion The combined treatment of SAM and Polyene Phosphatidylcholine can obviously improve the outcome of pregnancy and the newborns' quality of life than the single SAM or single Polyene Phosphatidylcholine.