Metabolic treatment of pregnancy and postdelivery period in a patient with cobalamin A disease

Abstract Objective: We report the successful treatment of a woman with Cobalamin A disease with hydroxycobalamin injections during pregnancy and delivery and 3 months after delivery. Urine and plasma methylmalonic acid levels served to adjust therapy before and after delivery. The mother had no untoward metabolic complications and gave birth to a normal baby. (Am J Obstet Gynecol 2002;187:225-6.)