Mitigation of myocardial ischemia-reperfusion injury via HIF-1α-frataxin signaling.

myocardial infarction (MI) is a leading cause of death and disability globally that typically results from the abrupt occlusion of an epicardial coronary artery ([9][1]). As a result, cardiomyocytes distal to the occlusion are subject to oxygen and nutrient deprivation, which triggers mitochondrial