PENGARUH EKSTRAK DAUN DAN BUAH KETAPANG (Terminalia catappa) TERHADAP MALONDIALDEHIDA PANKREAS TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR DENGAN HIPERGLIKEMIA YANG DIINDUKSI ALOKSAN DAN DIBERI PAKAN TINGGI LEMAK

Diabetes mellitus is a chronic disease caused by high levels of blood glucose. A high-fat diet can cause hyperglycemia .Hyperglycemia will cause the formation of free radicals which can damage cells. Aloksan is a chemical that can damage beta cells, resulting in decreased insulin production. Ketapang ( Terminalia catappa ) is a plant that can be used because of its antioxidant content. The administration of ketapang extract ( Terminalia catappa ) is thought to reduce levels of malondialdehyde. Malondialdehyde is a biomarker for the occurrence of lipid peroxidation in the body caused by an increase in free radicals due to the occurrence of oxidative stress. This study used Wistar rats divided into 4 groups. Three groups will be given high-fat diet for 7 days followed by induced alloxan at a dose of 90 mg / kgBW to increase blood glucose levels and pancreatic malondialdehyde levels. Then 2 groups will be given treatment for 14 days. The first treatment group was given Ketapang extract with a dose of 600 mg / kgBW and the second treatment group which was given glibenclamide using a dose of 0.09 mg / kgBW. The results showed that there was a significant decrease in pancreatic malondialdehyde in  Wistar rats induced by  glibenclamide (p = 0.016). In the group induced by ketapang leaf and fruit extract (Terminalia catappa) there was a decrease in malondialdehyde levels but was not significant (p = 0.916). Conclusions,  this study indicated that the administration of ketapang leaf and fruit ( Terminalia catappa ) extract were able to reduce the levels of pancreatic malondialdehyde given a high-fat diet and induced by alloxan.