GW25-e1594 Tongxinluo reduces infarct size by promoting endothelial adhesion junction integrity in reperfused diabetic hearts via PPAR-α pathway

Structural and functional disruption of microvascular barrier caused by ischemia/reperfusion results in uncontrolled inflammation and ischemia/reperfusion injury (IRI). Hyperglycemia may aggravate myocardial IRI since it worsens the barrier function. Whether Tongxinluo (TXL) is involved in