Non-alcoholic fatty liver disease is associated with chronic kidney disease and diabetic retinopathy in type 2 diabetic patients.

Objective To investigate the relationship of non-alcoholic fatty liver disease(NAFLD) with chronic kidney disease(CKD) and diabetic retinopathy(DR) in type 2 diabetic patients.Methods Prevalences of CKD and DR were assessed in 448 type 2 diabetic patients,who were divided into two groups by the presence of NAFLD.Results (1)The prevalence of NAFLD was 59.4% in type 2 diabetic patients.(2)NAFLD patients had remarkably(P0.01)higher urinary albumin/creatinine ratio(UACR) and prevalences of CKD(30.8 vs 18.1%) and DR(35.7 vs 21.4%) than their counterparts without NAFLD.(3)Logistic regression analysis showed that NAFLD was associated with increased incidences of CKD(OR=1.9,P0.05) and DR(OR=2.8,P0.01) independent of age,sex,diabetes duration,BMI,hypertension,smoking,HbA1c and serum lipids.Conclusion NAFLD is associated with increased prevalences of CKD and DR in type 2 diabetic patients.Early identification and intervention of NAFLD can help to prevent diabetic microvascular complications.