A quantitative morphological study of the effects of carbenoxolone sodium on duodenal goblet-cells of the rat.

Abstract 1. 1. A direct microscopic and microdensitometric examination was carried out on duodenal goblet-cells of non-fasted and fasted rats with and without carbenoxolone sodium treatment. 2. 2. The results of microdensitometric examination revealed a marked and significant increase of mucus production in the non-fasted and fasted rats pretreated for 2 hr with a single oral dose of carbenoxolone sodium at 100 mg/kg. Fasting alone also increased mucus production. 3. 3. On microscopic examination, the number of duodenal goblet-cells full of mucosubstances in the non-fasted and fasted rats receiving carbenoxolone sodium treatment was approximately 20% higher than in the controls.