Hypernatremia in Acute Myeloid Leukemia With Trisomy 13: A Case Report and Review of Literature of Diabetes Insipidus in Association With Acute Myeloid Leukemia

Diabetes insipidus (DI) is a disorder characterized by the inability of the body to conserve water. It occurs either via a central mechanism, where anti-diuretic hormone (ADH) is deficient, or via a nephrogenic mechanism characterized by normal ADH secretion and varying degrees of renal resistance to its water-retaining effects. Central DI is mostly idiopathic, but it can be secondary to trauma, surgery, tumors, infections or other infiltrative processes in the brain. Acute myeloid leukemia (AML) is a rare association with central DI, particularly when there are karyotype abnormalities such as monosomy 7 or inversion of chromosome 3q. Here we report a case of DI associated with AML without these chromosomal abnormalities, but with trisomy 13 in a 19-year-old Haitian female. J Hematol. 2014;3(3):80-83 doi: http://dx.doi.org/10.14740/jh125w