Whole-exome sequencing in early-onset Parkinson’s disease among ethnic Chinese
2020
Abstract Although early-onset Parkinson’s disease (EOPD) has a more penetrant genetic etiology, the genetic architecture of EOPD remains unclear. The objectives of this study were to assess the genetic and clinical features of EOPD among ethnic Chinese from mainland China. Using whole-exome sequencing (WES), we performed genetic analyses of 240 participants including 193 with sporadic and 47 with familial EOPD (age of onset
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