Abstract 312: Selective Inhibition of Myocardial NADPH Oxidase Significantly Decreases Heart Size in Transgenic (Tg) Mice with Cardiac-Specific Overexpression of a Dominant-Negative (DN) Mutant of p67phox

Qiong Zhao,Magdalena Ornatowska,Dalia Urboniene,Kristopher McGee,R. J. Solaro,Roberta Franks,John W. Christman,Lei Xiao

Abstract 312: Selective Inhibition of Myocardial NADPH Oxidase Significantly Decreases Heart Size in Transgenic (Tg) Mice with Cardiac-Specific Overexpression of a Dominant-Negative (DN) Mutant of p67phox

2008

Qiong Zhao
Magdalena Ornatowska
Dalia Urboniene
Kristopher McGee
R. J. Solaro
Roberta Franks
John W. Christman
Lei Xiao

The role of NADPH oxidase (NOX) was recently suggested in cardiac diseases including hypertrophy. Overexpression of a DN mutant of p67phox, a cytosolic subunit of NOX, DN-p67 with a V204A point mut...

Keywords:

Mutant
Heart size
Transgene
Diabetes mellitus
NADPH oxidase
Medicine
Molecular biology
selective inhibition
dominant negative

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