TO STUDY THE EFFECT OF COMBINATION OF METFORMIN, GLIMEPRIDE VOGLIBOSE IN TCF7L2 GENE ASSOCIATED TYPE 2 DIABETESMELLITUS.

Background:The TCF7L2-gene (TCF7L2; Transcription factor 7-like 2) involves in regulation of cellular proliferation and differentiation. It also increased risk for type 2 diabetes (T2D), dose effect were reported for the rs7903146 variant. The risk alleles of TCF7L2 gene involves in progression of impaired glucose tolerance to diabetes prospectively and an increased severity of the disease Material and Methods:Prospective, randomised study. Combination of Metformin, Glimepride Voglibosehas been prescribed in TCF7L2 gene associated type 2 diabetes mellitus patients s Results: TCF7L2 gene is associated with Type 2 diabetes mellitus. Genetic investigation was done in all 40 patients three genotypes have been identified 10 patients were on CC, 12 patients were on CT and 18 patients were on TT genotypes.Baseline values are higher in TT genotype when compared with CT & CC genotypes. There were significant improvement in blood glucose levels were as a controlled lipid profile was observed in CC genotype but no significant was observed in CT, TT and in group Conclusion:Patients HbA1c ranges from