Analysis on risk factors of severe myelosuppression after the treatment of NK/T cell lymphoma, nasal type

Objective To investigate the risk factors of occurring severe myelosuppression after the treatment of NK/T cell lymphoma, nasal type. Methods A total of 108 patients with NK/T cell lymphoma, nasal type treated in the First Affiliated Hospital of Zhengzhou University from June 2010 to September 2016 were selected. And they were divided into severe bone marrow suppression group (56 cases) and non-severe bone marrow suppression group (52 cases), according to treatment methods. Univariate and multivariate Logistic regression were used to analyze the risk factors of severe bone marrow suppression. Results Body surface area (OR=0.167, 95% CI: 0.045-0.614, P=0.007), diagnostic staging (OR=1.569, 95% CI: 1.071-2.298, P=0.021), treatment regimen (OR=1.315, 95% CI: 1.096-1.578, P=0.003) were risk factors of severe bone marrow suppression. The incidence of severe bone marrow suppression (52.4%) of DDGP was lower than that of the improved SMILE regimen (75.0%), with significant differences (P<0.05). Conclusions The risk factors of severe myelosuppression after the treatment of NK/T cell lymphoma, nasal type were surface area, diagnosis stage and treatment regimen. Severe bone marrow suppression should be alert in clinical application of the improved SMILE protocol, and the DDGP protocol is worthy of promotion. Key words: Natural killer T cell lymphoma; Myelosuppression; Logistic multivariate analysis