Association of gamma-glutamyl transpherase activity with electrocardiographic indicators in coronary artery disease patients

0 0 1 14 85 OMU Medical Faculty 1 1 98 14.0 544x376 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} 0 0 1 230 1315 OMU Medical Faculty 10 3 1542 14.0 544x376 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} Gamma-glutamyl transpherase (GGT) plays an important role in atherogenesis through its activity in oxidative processes, which has been demonstrated in clinical studies . The connection between serum GGT activity and noninvasive arrhythmia indicators in patients with coronary artery disease (CAD) is investigated in the present study. We examined patients (n = 254, 174 males, mean age 62 ± 8) diagnosed with coronary artery disease on the basis of clinical and angiographic findings. All patient data were assessed, including serum GGT activity, biochemical measurements, and demographic and electrocardiographic features. A positive correlation was found between GGT levels and P-wave dispersion (r = 0.299, p < 0.0001); however, there was a negative correlation between GGT and ejection fraction (r = 0.216, p < 0.001). On the other hand, no correlation was found between GGT and the following: Sokolow-Lyon voltage, Cornell voltage, Cornell product, corrected QT, and QT dispersion (p values are 0.728, 0.892, 0.551, 0.069, and 0.146, respectively). When the patients were grouped according to gender, a significant association of GGT with P-wave dispersion and ejection fraction was observed in both of the groups. Nonetheless, a significant correlation between GGT and QTc was only found in the female group. In this study, we found that increased GGT activity was correlated with P-wave dispersion. These results indicate that there might be an increased risk of arrhythmias especially the atrial fibrillation in this patient population.