증례 : Thiazide 계 이뇨제에 의한 호중구 침윤이 현저한 급성 간질성 신염 1 예

Drug-induced acute interstitial nephritis, induced by unknown immunologic mechanisms, is inflammatory lesions of the tub3ointerstitial area due to several kinds of drugs as hapten and a rare, but increasingly recognized cause of acute renal failure. Drugs implicated include not only methicillin and other penicillins but also diuretics and nonsteroidal anti-imflammatory agents. Diagnosis of acute interstitial nephritis is important, because withdrawal of the offending agent will usually result in rapid improvement in renal function, and steroid therapy may reduce residual chronic renal damage. We are reporting a case of diuretic-induced acute interstitial nephritis in a 49 year-old female patient, who was given hydrochlomthiazide to treat hypertension. A percutaneous biopsy showed tubulointerstitial nephritis accopanying prominent neutrophil infiltration without glomerulitis. Withdrawal of the drug and use of corticosteroid led to remarkable improvement with renal function returning to normal.