Protective Effect of Danhong Injection in Patients with Acute Myocardial Infarction at a High Risk of No-reflow During Primary Percutaneous Coronary Intervention

Objective: To observe the effect of Danhong injection (DI) in patients with acute ST-segment elevation myocardial infarction (STEMI) at a high risk of no-reflow (NR) during primary percutaneous coronary intervention (PCI). Methods: Patients were placed in a DI group and control group. The DI group was given DI and the control group was given physiologic saline. The administration lasted 4 to 6 days in both groups after PCI. Cardiac magnetic resonance (CMR) was carried out during the perioperative period (7 ± 2 days). The primary endpoint of the study was myocardial infarct size (IS) imaged on delayed-enhancement CMR. The secondary endpoint was major adverse cardiac events observed 6 months after PCI. Results: In total, 160 high-risk NR patients were enrolled, and 110 patients completed the CMR examination. According to postoperative CMR, the Myocardial Salvage Index and left ventricular ejection fraction were higher in the DI group (0.57 ± 0.13 vs. 0.48 ± 0.17, P 0.05). Conclusion: The application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI.