Moleculobiological characteristics of oral squamous cell carcinomas
2011
Oral squamous cell carcinomas (OSCCs) are associated with poor prognosis, and
despite advances in therapy approaches, no major improvement in survival has
been achieved in the recent years. Efforts are now directed toward finding
new biological markers that could predict tumor behavior more accurately.
OSCCs, as the majority of malignant tumors, arise from progressive
accumulation of genetic and epigenetic lesions, transforming normal cells
into malignant. In this paper, an analysis of current studies directed to
understanding the underlying mechanisms of OSCC pathogenesis was presented.
The emphasis was put on mutational analysis of cancer genes, as well as on
the role of viral infections and methylation processes in OSCC. Finally, an
overview of studies that tried to determine the possibility for developing
OSCC was given.
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