The Swedish trial in old patients with hypertension-2(STOP-Hypertension-2): A progress report

Lindholm LH, Hansson L, Dahlof B, Ekbom T, Hedner T, de Faire U, Schersten B, Wester P-O. The Swedish trial in old patients with hypertension-2 (STOP-hypertension-2): a progress report.Objective: The Swedish Trial in Old Patients with Hypertension-2 (STOP-Hypertension-2) was designed by a project group of the Swedish Hypertension Society to test whether the “newer” treatment alternatives (ACE inhibitors and calcium antagonists) are as good as, better or less good than, the “older” ones (beta-blockers and diuretics) in terms of preventing cardiovascular morbidity and mortality in elderly hypertensives. The aim of the present paper is to report on the progress of the study.Design: Prospective, open trial with blinded end-point committee and centralized randomization (PROBE design). STOP-Hypertension-2 may be regarded as a scientific follow-up of the previously published Swedish Trial in Old Patients with Hypertension (STOP-Hypertension-I) (6) using the same study organization.Subjects: By the end of 1994 wh...