Analysis of factors related to drug-induced corneal lesions after cataract surgery

Objective To analyze the related factors of drug-induced corneal lesions after cataract surgery.Methods 197 eyes of 193 cases who used tobramycin dexamethasone eye drops after cataract surgery were enrolled in this retrospective study.Totally 25 eyes of 24 cases were diagnosed as drug-induced corneal lesions.The factors related to drug-induced corneal lesions were analyzed.Results Most druginduced corneal lesions were taken placed at 2 to 3 weeks after surgery and the main corneal lesion was superficial punctate corneal opacity.Hypertension,diabetes and aging were the most common risk factors which related to drug-induced corneal lesions (P ＜ 0.05).The relevance in lesion group was higher than that in normal group and the difference was statistically significant (x2 =7.90,P =0.01 ;x2 =10.41,P =0.00 ; x2 =8.95,P =0.00).The vision acuity and visual recovery time of normal group were better than that of lesion group (x2 =5.63,P =0.02; t =12.20,P =0.01).Conclusion After cataract surgery,need to be taken seriously for drug-induced corneal lesions which can harm postoperative visual acuity,especially for elderly patients and patients with hypertension or diabetes. Key words: Cataract;  Lesions, corneal, drug-induced;  Eye drops, tobramycin dexamethasone