AB1089 CLINICAL FEATURES OF FAMILIAL MEDITERRANEAN FEVER PATIENTS IN NORTH-WESTERN PART OF TURKEY: ANALYSIS OF 139 PATIENTS

Background Familial Mediterranean fever (FMF) is known the most common monogenic autoinflammatory disease. Its prevalence is reported high from the eastern Mediterranean areas (1) The disease is characterized by episodes of fever, serositis, arthritis,renal complications and other different clinical manifestations (2) Objectives Here, we aimed to present our data of our 139 FMF patients for demonstrating the demographic and clinical features of the study group,from North-western part of Turkey. Methods A total of 139 FMF patients who were diagnosed and treated in the department of Internal medicine/Rheumatology, Sakarya University (North-western area of Turkey) were included in the study and the demographic and clinical characteristics of the patients were examined. Results The mean age of the patients was 39.02 ± 11.3. Male gender was 42 (30.2%) and female gender was 97 (69.8%).107 (77%) of patients had fever and 32 (23%) had no history of fever. 127 (91.4%) patients complained about peritonitis, 27 (%19.4) patients had pleuritic pain, 19 (13.7%) patients had erysipelas like erythema and 53 (38.1%) patients had arthritis attack. 34 (24.5%) patients also had sacroiliitis. The ratio of resistance of treatment response to colchicine drugs that can be available in Turkey (Colchicum dispert®), 6 (4.3%) was determined. Interestingly these patients responded to the colchicine drugs available from some other countries from Europe (as Colchicine-opocalcium® and Colchicina-lirca®) None of our patients needed anti-IL1 therapies. The rate of amyloidosis was 5 (3.6%). Conclusion FMF is a disease with high morbidity and mortality, 95.7% of the patients in our region have response to colchicine drugs which is available in our country. The remaining patients have also response to colchicine available from some other countries. None of our patients had anti-IL1 therapies. References [1] ozen S, Batu ED, Demir S. Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management. Front Immunol. 2017 23;8:253. [2] Alghamdi M. Familial Mediterranean fever, review of the literatureClin Rheumatol. 2017;36:1707-1713. Disclosure of Interests None declared