THU0284 Predicting survival in 6240 patients with primary sjÖgren' syndrome (big data sjÖgren project)

Objectives To correlate the main features at diagnosis with survival in a multicenter international cohort of patients with primary Sjogren syndrome (SS). Methods The Big Data Sjogren Project was formed in 2014 to take a “high-definition” picture of the main features of primary SS by merging international SS databases (9302 consecutive patients recruited from 21 countries of the 5 continents) Results Data about survival at the last visit was available in 6240 patients (5831 women, mean age at diagnosis of 53yrs, 82% White). After a mean follow-up of 7.1yrs, 407 (6%) patients died. Patients who died were more frequently men (10% vs 6%, p=0.004) and White (96% vs 81%, p Conclusions An older age at diagnosis, male gender and serum cryoglobulins were the principal risk factors associated with death in this large multiethnic cohort of patients with primary SS. Disclosure of Interest None declared