Synthesis and evolution of polymeric nanoparticles

Abstract Polymeric nanoparticles have been widely explored in the field of pharmaceutics and biotechnology since its inception. Among the available family of nanocarriers, polymeric vectors have attracted much attention, owing to several beneficial properties such as: biocompatibility, biodegradability, nonimmunogenicity, and nontoxicity. Recently, gene delivery via polymer nanoparticles has gained tremendous attention as an efficient and safe vector. Progress has also been made in designing potent, stable nanoparticles for tissue/cell targeting by conjugating ligands to the polymeric nanoparticles. Altogether, these advancements have improved the performance of nanoparticles. Researchers have made several efforts to overcome the challenges and barriers posed toward its clinical development. A number of preclinical reports regarding polymeric nanoparticles–assisted gene delivery are already in the pipeline, providing clear evidence that the polymeric nanoparticles can find their way into clinic and will have a significant impact on therapeutics.