Lung cancer in never smokers. An update of the Lung Cancer Risk Factors in Never Smokers Study (LCRINS)

Introduction: Lung cancer in never smokers is the 7th cause of cancer if considered as a separate disease. Nevertheless, there is scarce research of lung cancer in never smokers (LCNS). We aim to describe lung cancer characteristics in a cohort of never smokers recruited in Spain. Methods: We designed a multicentre, hospital-based, case-control study. All lung cancer cases who fulfilled the definition of a never smoker (a. had smoked less than 100 cigarettes during lifetime, or b. had smoked less than 1 cig/day during six months) were consecutively recruited. All cases had to be older than 30 with histological confirmation of lung cancer. All participants were personally interviewed with special emphases on lifestyle. Residential radon was measured in all participants. Data analysis was performed with SPSS v22. Results: 389 cases were included until June 2016. 19% males, median age was 71 years old, P25-75: 61-78. Men were younger than women (66 vs 71; p Conclusions: Adenocarcinoma is the most frequent histological type in never smokers. Women are diagnosed at an older age than men. Lung cancer in never smokers is diagnosed lately. Residential radon seems to play an important role on the onset of this disease in never smokers.