Effects of high-dose RU-486 treatment on climacteric complaints in hysterectomized postmenopausal women: a 6-week pilot study

We investigated the effect of the anti-progestogen mifepristone (RU-486) on climacteric complaints. Four hysterectomized postmenopausal women, with at least 35 hot flushes per week, were treated with daily 200 mg RU-486 for 6 weeks. RU-486 did not significantly improve climacteric complaints. Although this result does not support further clinical research with this dose of RU-486 for the treatment of climacteric complaints, potential effects of higher, but more interestingly of lower, dosages of RU-486 cannot be excluded.