Effect of Myeloma Light Chains on Phosphate and Glucose Transport in Renal Proximal Tubule Cells

Vecihi Batuman,Shangbo Guan,Richard O’Donovan,Jules B. Puschett

Effect of Myeloma Light Chains on Phosphate and Glucose Transport in Renal Proximal Tubule Cells

1994

Vecihi Batuman
Shangbo Guan
Richard O’Donovan
Jules B. Puschett

Primary cultures of cells derived from the rat proximal tubule were exposed to up to 200 µ M λ- or χ-light chain obtained from myeloma patients. Light chains inhibited the uptake of

Keywords:

Endocrinology
Glucose transporter
Bence Jones protein
Nephrotoxicity
Internal medicine
Multiple myeloma
Cell culture
Diabetes mellitus
Phosphate
Immunoglobulin light chain
Medicine
Ion transporter
Molecular biology
Myeloma protein

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