Echocardiographic Abnormalities and Determinants of 1-month Outcome of Stroke Among West Africans in the SIREN Study (1606)

Objective: We investigated the pattern and association of baseline echocardiographic variables with 1-month disability and mortality among patients with stroke in the SIREN study. Background: Certain transthoracic echocardiography features such as left atrial volume, spontaneous echo contrast or “smoke,” increased left ventricular (LV) mass, and poor LV functions have been previously associated with stroke and stroke outcome. Despite the aforementioned, the current recommendations for the management of acute stroke does not consider echocardiography as an essential test in patients with stroke. As a result, little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. Design/Methods: The SIREN study is a multicenter case-control investigation that involves 15 sites in Ghana and Nigeria. We enrolled and followed up consecutive 1020 adult patients with acute stroke with baseline transthoracic echocardiography from West Africa. To explore the relationship between echocardiographic variables and 1-month disability (using modified Rankin scale >3) and fatality, regression models were fitted. Relative risks were computed with 95% Cis. Results: The participants comprised 60% men with a mean age of 59.2±14.6 years. Ischemic stroke was associated with smaller aortic root diameter (30.2 versus 32.5, P=0.018) and septal (16.8 versus 19.1, P Conclusions: 9/10 patients with acute stroke had abnormal LV geometry and 1/3 had SD. This was significantly associated with 1 month mortality. Larger studies are required to establish the independent effect and unravel predictive accuracy of this association. Disclosure: Dr. Owolabi has nothing to disclose. Dr. Adeoye has nothing to disclose. Dr. Akinyemi has nothing to disclose. Dr. Ogah has nothing to disclose. Dr. Akinyemi has nothing to disclose. Dr. Gebregziabher has nothing to disclose. Dr. Wahab has nothing to disclose. Dr. Fakunle has nothing to disclose. Dr. Akintunde has nothing to disclose. Dr. Adebayo has nothing to disclose. Dr. Aje has nothing to disclose. Dr. Tiwari has nothing to disclose. Dr. Arnett has nothing to disclose. Dr. Agyekum has nothing to disclose. Dr. Appiah has nothing to disclose. Dr. Amusa has nothing to disclose. Dr. Olunuga has nothing to disclose. Dr. Akpa has nothing to disclose. Dr. Sarfo has nothing to disclose. Dr. Akpalu has nothing to disclose. Dr. Jenkins has nothing to disclose. Dr. Lackland has nothing to disclose. Dr. Owolabi has nothing to disclose. Dr. Komolafe has nothing to disclose. Dr. Faniyan has nothing to disclose. Dr. Arulogun has nothing to disclose. Dr. Obiako has nothing to disclose. Dr. Ovbiagele has nothing to disclose.