Influence of symptomatic status on the prevalence of obstructive coronary artery disease in patients with zero calcium score

Background: CAC has been used to predict obstructive CAD on invasive coronary angiography. However, it is unknown how the prevalence of obstructive CAD in patients with zero CAC is influenced by the presence or absence of chest pain. Methods: 210 consecutive patients referred for CAC and CorCTA were included in this analysis. Chest pain was defined based on the Diamond-Forrester classification. Results: 134 patients (64%) were symptomatic and 76 (36%) were asymptomatic. Seventy patients had negative (33%); 140 had positive CAC (67%). In the symptomatic group with zero CAC, 8.2% (4/49) had an obstructive, non-calcified plaque; of these, 3 were 45 years compared to younger patients to exclude obstructive CAD (AUC: 0.83 vs. 0.5, p < 0.001; NPV = 0.98). Conclusions: CAC is better in asymptomatic compared to symptomatic subjects, especially in patients

Keywords:

• Asymptomatic
• Calcium score
• Coronary artery disease
• Angiography
• Computed tomography
• Vascular disease
• Chest pain
• Diabetes mellitus
• Cardiology
• Internal medicine
• Medicine
• in patient
• invasive coronary angiography

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