OXALIPLATIN-BASED THERAPY: STRATEGIES TO PREVENT OR MINIMIZE NEUROTOXICITY

ABSRACT:Backbone :Oxaliplatin is an anticancer drug used to treat some different neoplasms: lung, colorectal, ovarian, breast, head/neck, and genitourinary. Moreover, patients treated with ox aliplatin more often discontinue therapy due to peripheral neuropathy and not to tumor progres sion. Patient benefit is potentially compromising. Several strategies are been investigated to prevent neurotoxicity. Content: In order to overcome this life-altering side effect, while taking advantage of the antineoplastic activities of the oxaliplatin, we detail recent findings of the , most common available strategies methods for prevention/minimize neurotoxicity. These include: a) variation of the standard scheduling; b) addition of various neurological drug to standard protocol; c) use of “natural” an tioxidant agents. Summary : Based on these actions, the oncologists will have a new issues with which to make treatment decisions for their patients to maximize benefit and minimize neurotoxicity. Based on this purpose, the clinician and pharmacists may join to evaluate advantages and limitation, in terms of costs and applicability, of the most appropriate strategies to incorporate routinely into clinical practice .