Headache in patients with isolated cortical vein thrombosis: report of 9 cases and review of the literature. (P3.112)

Objective: NA Background: Isolated cortical vein thrombosis (ICVT) is a rare type of cerebral venous infarction, and its diagnosis is often delayed. Headaches have been the most commonly reported symptom of ICVT. We aimed to delineate the clinical profile and headache characteristics of patients with ICVT. Design/Methods: We presented 9 patients with ICVT and systemically reviewed the published cases. Patients with and without headache were compared to investigate the headache characteristics and clinical profiles associated with ICVT. Results: In this report, a total of 86 ICVT cases were included, and 54 (62.8%) of them reported headaches. Compared with ICVT patients without headache, the patients experiencing headache were younger (37.4±14.4 versus 46.5±19.4 years; P=0.039) and were less likely to have seizure (48.1% versus 83.9%; P=0.001). In the analysis regarding risk factors, dural puncture (33.3% versus 6.9%, P=0.001), epidural blood patch (14.8% versus 0%, P=0.025) and pregnancy or puerperium (100% versus 0%, P=0.012) were more common among patients with headache than among those without headache. The headaches were primarily acute or sudden onset (78.6%), severe in intensity (88.0%) and ran a monophasic course (87.0%). Conclusions: Headache is a common presentation of ICVT. The delineation of headache characteristics and associated clinical parameters may help in the early recognition of ICVT. Disclosure: Dr. Cheng has nothing to disclose. Dr. Lai has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lai has nothing to disclose.