GW27-e0703 The effect of Candesartan on TLR7 expression and downstream inflammation in THP-1 macrophages and its mechanism

BACKGROUND Accumulating evidence suggested that angiotensin type 1 receptor (AT1R) playing an important role in the development of atherosclerosis (AS). Angiotensin II (AngII) can induce vessel wall inflammation and regulate the release of inflammatory factors and adhesion factors through NF-κB