La asociaciÓn con papiloma virus humano, no modifica la incidencia de lesiones intraepiteliales del epitelio escamoso estudio comparativo de dos poblaciones

2001 
23,748 women are routinely studied to whom cytology, colposcopy and uterine cervical biopsy is done, 821 of which have different grades of SIL, carcinoma in situ and invasive carcinoma distributed as follow: 1) Low grade SIL that includes: a) CIN I (light displasia) with and without HPV: 500 patients. b) CIN II (moderate displasia) with and without HPV: 242 patients. 2) High grade SIL: CIN III (severe displasia) with and without HPV and CIS (carcinoma in situ) is added: 54 patients. 3) Invasive carcinoma: 25 patients (without HPV). The two populations that have and don't show HPV are compared, and the following conclusions are reached, the ones that constitute the objetive of the presentation: 1) The association with infection by HPV doesn't modify the frequency of presentation of displasias (different grades of SIL) and uterine cervical carcinoma: a) In CIN I there aren't nearly differences between the population that doesn't have HPV and the one that it has (59,4% and 40,6%, respectively). b) Moreover: in CIN II y III the non-infected group predominantes (80.5% and 92.5% respectively). c) As regards invasive carcinoma, 100% of the researched population is HPV negative. 2) Consequently, we can infer that despite being HPV one of the possible candidates responsible for displasic and carcinomatosa lesions, it is not the only agent that causes cervical cancer, but, others cofactors are required (age: 20-40 years old; race: white versus black people, sexual promiscuity, usage of oral contraceptives, smoking habit, pregnancy, immunosuppression etc.), that synergically act together with it such as is the trend of nowadays' thought.
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